Using DermGem Application Debride and prepare the wound using best wound care practices.Remove DermGEN™ from its package.Measure wound and trim DermGEN™ to match wound size.Place DermGEN™ with the dermal side in contact with the woundbed.Use a dressing with a non-contact layer and moisture control over DermGEN™.Use effective off-loading such as total contact casting or appropriate orthotic.